Ventilation is the deliberate exchange of indoor air with outdoor air. Older leaky houses did much of it by accident; tighter houses do not, and many have no continuous ventilation system at all. Indoor carbon dioxide is commonly used as an indicator of outdoor-air supply relative to the number of people in a room — not as a general index of air quality.
Humidity affects comfort, materials, condensation and microbial growth potential, and in a humid climate it is mostly a question of equipment runtime, airflow across the coil and whether ducts are importing outdoor moisture.
Filtration addresses airborne particles, and only to the extent the blower and duct system can move air through the media without losing airflow. Particle filters do not remove gases; sorbent media such as activated carbon can reduce some gases depending on the compound, the amount of media and airflow.
Pollutant sources — building materials, furnishings, finishes, cleaning and personal-care products, cooking, attached garages and moisture problems — matter more than any air cleaner, which is why source control comes first in EPA guidance.
Combustion safety is the one category here that is life safety rather than comfort. It is handled with listed carbon-monoxide alarms, correct venting and combustion air, and appliance testing against the manufacturer's published specifications.
HVAC performance underlies all of it. A system that cannot deliver its design airflow, or that leaks duct air into an attic, changes filtration, humidity control and the pressures around fuel-burning appliances at the same time. That is what a Comfort Audit measures.